Sinclair Method Studies
Published on: 11/06/2025
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
Dr David Sinclair: The Research Legacy Behind The Sinclair Method
Bruce Rose Published on: 11/06/2025
The Sinclair Method didn’t originate in a corporate lab or a detox facility—it started in a Helsinki research centre. Dr John David Sinclair, a behavioural psychologist from the United States, moved to Finland in the early 1970s after completing his PhD. There, he joined Alko Laboratories, the research arm of Finland’s state alcohol monopoly, which would later become part of the country’s National Public Health Institute.
The Sinclair Method (TSM)
Is Naltrexone Available in the UK and Ireland? What You Need to Know
Bruce Rose Published on: 28/05/2025
Naltrexone is a non-addictive opioid antagonist that blocks the brain’s ability to feel pleasure from alcohol. Over time, drinking becomes less rewarding, reducing cravings and consumption naturally — a process known as Pharmacological Extinction. This effect is the foundation of The Sinclair Method (TSM), where individuals take Naltrexone only prior to drinking, gradually reprogramming their brain’s response to alcohol.
The Sinclair Method (TSM)
Why Support Programme is So Important with TSM – Naltrexone Is Not ‘Just’ a Magic Pill Blog Post
Bruce Rose Published on: 13/05/2025
Naltrexone plays a vital role in the Sinclair Method (TSM), blocking the brain’s reward response to alcohol and gradually reducing the desire to drink.
The Sinclair Method (TSM)
Naltrexone: Your Guide to Overcoming Alcohol Cravings
Published on: 28/03/2025
Overcoming alcohol cravings isn’t about willpower — it’s about changing how the brain reacts to alcohol. That’s where Naltrexone comes in. This medication, when used correctly, can interrupt the reward cycle that fuels compulsive drinking. In this guide, we’ll explore exactly how Naltrexone works, what cravings really are, and how this medication rewires the brain's response to alcohol.
The Sinclair Method (TSM)
